Defense

The amount of damage prevented each time an engage or ability deals damage to a unit.

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FAQ

How often enemy defense get applied?

Defense applies to each instance of damage that you deal to a unit, preventing damage equal to the stat. Note that an engageEngageAdventurers may engage multiple times per turn but are limited by the dice they can roll and fatigue they can gain. You may perform a move action before or after you perform an engage action, but not both. is considered a single instance of damage even if multiple different skills deal damage within the engage. This damage prevention applies even outside of turns.

Source